Immunoreactivity for Interleukin-33 in Allergic Airway Inflammation

Soluble St2 Blocks Il-33 Signaling in Allergic Airway Inflammation

SOLUBLE ST2 BLOCKS IL-33 SIGNALING IN ALLERGIC AIRWAY INFLAMMATION Hiroko Hayakawa1, Morisada Hayakawa1, Akihiro Kume2, and Shin-ichi Tominaga1 From the 1Department of Biochemistry and 2Division of Genetic Therapeutics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan Running Title: Suppression of IL-33 signaling by soluble ST2 Address correspondence to: Moris...

Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.

Recent data indicate that the proinflammatory cytokine, interleukin (IL)-17, stimulates certain effector functions of human macrophages. We evaluated whether IL-17 mediates allergen-induced accumulation of airway macrophages and, if so, whether such an effect relates to the control of macrophage recruitment and survival. BALB/c mice were sensitized and challenged with ovalbumin. Three hours bef...

IL-33 and Airway Inflammation

Interleukin-33 (IL-33) is the 11th member of IL-1 cytokine family which includes IL-1 and IL-18. Unlike IL-1β and IL-18, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage and may not enhance acquired immune responses through activation of inflammasome. ST2, a IL-33 receptor component, is preferentially expressed by T-helper type (Th) 2 cell...

Allergic Airway Inflammation

Surfactant and allergic airway inflammation.

Pulmonary surfactant is a complex mixture of unique proteins and lipids that covers the airway lumen. Surfactant prevents alveolar collapse and maintains airway patency by reducing surface tension at the air-liquid interface. Furthermore, it provides a defence against antigen uptake by binding foreign particles and enhancing cellular immune responses. Allergic asthma is associated with chronic ...